Review





Similar Products

brain slices  (TaKaRa)
96
TaKaRa brain slices
Brain Slices, supplied by TaKaRa, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brain slices/product/TaKaRa
Average 96 stars, based on 1 article reviews
brain slices - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
g e mounted tissue slices  (Novus Biologicals)
94
Novus Biologicals g e mounted tissue slices
G E Mounted Tissue Slices, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/g e mounted tissue slices/product/Novus Biologicals
Average 94 stars, based on 1 article reviews
g e mounted tissue slices - by Bioz Stars, 2026-05
94/100 stars
  Buy from Supplier
frozen cerebral meninges glass mounted tissue slices  (Novus Biologicals)
94
Novus Biologicals frozen cerebral meninges glass mounted tissue slices
Frozen Cerebral Meninges Glass Mounted Tissue Slices, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/frozen cerebral meninges glass mounted tissue slices/product/Novus Biologicals
Average 94 stars, based on 1 article reviews
frozen cerebral meninges glass mounted tissue slices - by Bioz Stars, 2026-05
94/100 stars
  Buy from Supplier
brain slices expressing aav iglusnfr3  (Addgene inc)
93
Addgene inc brain slices expressing aav iglusnfr3
Brain Slices Expressing Aav Iglusnfr3, supplied by Addgene inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brain slices expressing aav iglusnfr3/product/Addgene inc
Average 93 stars, based on 1 article reviews
brain slices expressing aav iglusnfr3 - by Bioz Stars, 2026-05
93/100 stars
  Buy from Supplier
organotypic brain slice cultures obscs  (Dawley Inc)
86
Dawley Inc organotypic brain slice cultures obscs
(b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
Organotypic Brain Slice Cultures Obscs, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/organotypic brain slice cultures obscs/product/Dawley Inc
Average 86 stars, based on 1 article reviews
organotypic brain slice cultures obscs - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
thick medullary brain slice  (Charles River Laboratories)
86
Charles River Laboratories thick medullary brain slice
(b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
Thick Medullary Brain Slice, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/thick medullary brain slice/product/Charles River Laboratories
Average 86 stars, based on 1 article reviews
thick medullary brain slice - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
mouse posterior brain slice  (10X Genomics)
86
10X Genomics mouse posterior brain slice
(b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
Mouse Posterior Brain Slice, supplied by 10X Genomics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse posterior brain slice/product/10X Genomics
Average 86 stars, based on 1 article reviews
mouse posterior brain slice - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
brain slices  (Merck & Co)
86
Merck & Co brain slices
(b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
Brain Slices, supplied by Merck & Co, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brain slices/product/Merck & Co
Average 86 stars, based on 1 article reviews
brain slices - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
brain slices  (Biosensis ltd)
96
Biosensis ltd brain slices
(b) Live tumor cell bioluminescence four days post tumor tissue seeding on <t>OBSCs.</t> (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).
Brain Slices, supplied by Biosensis ltd, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/brain slices/product/Biosensis ltd
Average 96 stars, based on 1 article reviews
brain slices - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier

Image Search Results


(b) Live tumor cell bioluminescence four days post tumor tissue seeding on OBSCs. (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).

Journal: PLOS One

Article Title: An ex vivo functional biomarker of treatment response in pediatric low-grade glioma

doi: 10.1371/journal.pone.0331423

Figure Lengend Snippet: (b) Live tumor cell bioluminescence four days post tumor tissue seeding on OBSCs. (c) pLGG microtumor replicate viability measured via bioluminescent flux, with four statistical outliers showing increased viability compared to the average survival of each microtumor (*statistical outlier measured using ROUT method, Prism). (d) pLGG-1 viability on OBSC compared to in vitro , showing a 43-fold increase in survival on OBSC (****p < 0.0001 compared to pLGG-1 microtumors in vitro using Welch’s t test, Prism).

Article Snippet: We first tested the reproducible engraftment and survival of all three pLGG tumor tissues on SLiCE, which uses living organotypic brain slice cultures (OBSCs) from P8 Sprague-Dawley rat pups as living tissue substrates on which to engraft and treat patient tumor tissues.

Techniques: In Vitro

(a) RAS-MAPK pathway demonstrating the effects of the BRAF:KIAA 1549 fusion and targeted therapy with dabrafenib and trametinib. (b) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on organotypic brain slice cultures and treated with trametinib. (c) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on OBSCs and treated with dabrafenib. (d) Heatmap of trametinib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (e) Heatmap of dabrafenib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (f) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for trametinib treatment at 24 h and 72 h. (g) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for dabrafenib treatment at 24 h and 72 h.

Journal: PLOS One

Article Title: An ex vivo functional biomarker of treatment response in pediatric low-grade glioma

doi: 10.1371/journal.pone.0331423

Figure Lengend Snippet: (a) RAS-MAPK pathway demonstrating the effects of the BRAF:KIAA 1549 fusion and targeted therapy with dabrafenib and trametinib. (b) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on organotypic brain slice cultures and treated with trametinib. (c) Western blot of BRAF:KIAA 1549 + pLGG-1 cells seeded on OBSCs and treated with dabrafenib. (d) Heatmap of trametinib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (e) Heatmap of dabrafenib treatment-induced protein levels of pMEK, tMEK, pERK, and tERK after 24 and 72 hours. (f) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for trametinib treatment at 24 h and 72 h. (g) Heatmap of normalized band intensities (pERK/tERK and pMEK/tMEK) for dabrafenib treatment at 24 h and 72 h.

Article Snippet: We first tested the reproducible engraftment and survival of all three pLGG tumor tissues on SLiCE, which uses living organotypic brain slice cultures (OBSCs) from P8 Sprague-Dawley rat pups as living tissue substrates on which to engraft and treat patient tumor tissues.

Techniques: Western Blot, Slice Preparation